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PDB entry 1dbh

DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1

The structure was published by Soisson, S.M., Nimnual, A.S., Uy, M., Bar-Sagi, D., and Kuriyan, J., in 1998 in a paper entitled "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTEIN (HUMAN SOS 1). This molecule has the UniProt identifier Q07889 (SOS1_HUMAN)search. The sample contained 354 residues which is < 90% of the natural sequence. Out of 354 residues 340 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HUMAN SOS 1) Q07889 (198-551) (SOS1_HUMAN)search Homo sapienssearch < 90% 354 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q07889 (198 - 551) PROTEIN (HUMAN SOS 1) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A DBL homology domain (DH-domain)search, Pleckstrin-homology domain (PH domain)search Dbl Homology Domain; Chain Asearch, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)search RhoGEF domainsearch, PH domainsearch, Core histone H2A/H2B/H3/H4search, motifsearch, RasGEF domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A Protein bindingsearch, Rho guanyl-nucleotide exchange factor activitysearch Intracellularsearch Regulation of rho protein signal transductionsearch

Chain InterPro annotation
A Dbl homology (DH) domainsearch, Ras-like guanine nucleotide exchange factor, N-terminalsearch, Pleckstrin homology domainsearch, Guanine-nucleotide dissociation stimulator CDC25search, Histone coresearch, Ras guanine nucleotide exchange factorsearch, Histone-foldsearch, Pleckstrin homology-like domainsearch, Ras GTP exchange factor, son of sevenlesssearch, Ras guanine-nucleotide exchange factor, conserved sitesearch, Ras guanine nucleotide exchange factor, domainsearch