1dan Summary

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Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor

The structure was published by Banner, D.W., D'Arcy, A., Chene, C., et al., Konigsberg, W.H., Nemerson, Y., and Kirchhofer, D., in 1996 in a paper entitled "The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This entry contains 22 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L BLOOD COAGULATION FACTOR VIIA light chain P08709 (61-212) (FA7_HUMAN)search Homo sapienssearch < 90% 152 93%
H BLOOD COAGULATION FACTOR VIIA heavy chain P08709 (213-466) (FA7_HUMAN)search Homo sapienssearch < 90% 254 100%
T SOLUBLE TISSUE FACTOR P13726 (37-116) (TF_HUMAN)search Homo sapienssearch < 90% 80 93%
U SOLUBLE TISSUE FACTOR P13726 (122-242) (TF_HUMAN)search Homo sapienssearch < 90% 121 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P08709 (61 - 212) BLOOD COAGULATION FACTOR VIIA light chain Homo sapiens
P13726 (37 - 116) SOLUBLE TISSUE FACTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L EGF-type modulesearch, GLA-domainsearch EGF-like domainsearch, Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domainsearch
H Eukaryotic proteasessearch Trypsin-like serine proteasessearch Trypsinsearch
T Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch
U Fibronectin type IIIsearch Immunoglobulinssearch Interferon-alpha/beta receptor, fibronectin type IIIsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
L (P08709) calcium ion bindingsearch extracellular regionsearch
H (P08709) proteolysissearch serine-type endopeptidase activitysearch catalytic activitysearch
T (P13726) blood coagulationsearch integral component of membranesearch
U (P13726) blood coagulationsearch integral component of membranesearch

Chain InterPro annotation
L EGF-type aspartate/asparagine hydroxylation sitesearch Gamma-carboxyglutamic acid-rich (GLA) domainsearch Epidermal growth factor-like domainsearch EGF-like calcium-binding domainsearch EGF-like, conserved sitesearch Coagulation factor, subgroup, Gla domainsearch EGF-like calcium-binding, conserved sitesearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
T Tissue factorsearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch
U Tissue factorsearch Fibronectin type IIIsearch Immunoglobulin-like foldsearch Interferon alpha/beta receptor, beta chainsearch