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PDBe Entry: 1d8f 
CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR.
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HYDROLASE
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X-RAY DIFFRACTION
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Resolution: 2.4 Å, R-factor: 29.4%, Free R-factor: 25.2%, Spacegroup: P 21 21 21
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23/10/2000, deposition: 22/10/1999, last revision: 24/02/2009
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Cheng, M.Y.; De, B.; Pikul, S.; Almstead, N.G.; Natchus, M.G.; Anastasio, M.V.; McPhail, S.J.; Snider, C.E.; Taiwo, Y.O.; Chen, L.Y.
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Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
J.MED.CHEM. vol:43, pag:369-380 (2000) [PubMed ID 10669564 ]
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MIXED ALPHA BETA STRUCTURE, ZINC PROTEASE, INHIBITED, HYDROLASE
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3.4.24.17 ExPASy BRENDA (A B)
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Homo sapiens(human) 9606(A B)
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Stromelysin-1 precursor (EC 3.4.24.17) (SL-1) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) P08254 (A B)
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A, B
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1cqr, 1d5j, 1d7x
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| A, B |
STROMELYSIN-1 PRECURSOR |
Protein |
P08254 (MMP3_HUMAN)
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173 |
100% |
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| A, B |
ZINC ION |
ZN
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| A, B |
CALCIUM ION |
CA
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| B |
N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYL-PIPERAZINE-2-CARBOXAMIDE |
SPI
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