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CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION

X-ray diffraction
2Å resolution
PDB entry 1d8d coloured by chain, front view.
PDB entry 1d8d coloured by chain, side view.
PDB entry 1d8d coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein farnesyltransferase complex and GTPase KRas, N-terminally processed
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Multimeric state: hetero trimer
Accessible surface area: 29133.81 Å2
Buried surface area: 10686.36 Å2
Dissociation area: 1,109.42 Å2
Dissociation energy (ΔGdiss): 18.87 kcal/mol
Dissociation entropy (TΔSdiss): 7.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134020

Macromolecules

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Chain: A
Length: 377 amino acids
Theoretical weight: 44.1 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04631 (Residues: 1-377; Coverage: 100%)
Gene name: Fnta
Pfam: Protein prenyltransferase alpha subunit repeat
InterPro: Protein prenyltransferase, alpha subunit
CATH: Protein prenylyltransferase
SCOP: Protein prenylyltransferase
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 1d8d, assembly 1, front view.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 1d8d, assembly 1, side view.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha in PDB entry 1d8d, assembly 1, top view.
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Protein farnesyltransferase subunit beta
Chain: B
Length: 437 amino acids
Theoretical weight: 48.72 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02293 (Residues: 1-437; Coverage: 100%)
Gene name: Fntb
Pfam: Prenyltransferase and squalene oxidase repeat
InterPro:
CATH: Glycosyltransferase
SCOP: Protein prenyltransferases
Protein farnesyltransferase subunit beta in PDB entry 1d8d, assembly 1, front view.
Protein farnesyltransferase subunit beta in PDB entry 1d8d, assembly 1, side view.
Protein farnesyltransferase subunit beta in PDB entry 1d8d, assembly 1, top view.
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GTPase KRas, N-terminally processed
Chain: P
Length: 11 amino acids
Theoretical weight: 1.3 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01116 (Residues: 185-189; Coverage: 3%)
Gene names: KRAS, KRAS2, RASK2
GTPase KRas, N-terminally processed in PDB entry 1d8d, assembly 1, front view.
GTPase KRas, N-terminally processed in PDB entry 1d8d, assembly 1, side view.
GTPase KRas, N-terminally processed in PDB entry 1d8d, assembly 1, top view.
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