1d7i Summary



The structure was published by Burkhard, P., Taylor, P., and Walkinshaw, M.D., in 2000 in a paper entitled "X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (FK506-BINDING PROTEIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (FK506-BINDING PROTEIN) P62942 (2-108) (FKB1A_HUMAN)search Homo sapienssearch 99% 107 100%
B PROTEIN (FK506-BINDING PROTEIN) P62942 (2-108) (FKB1A_HUMAN)search Homo sapienssearch 99% 107 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62942 (2 - 108) PROTEIN (FK506-BINDING PROTEIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62942) FKBP immunophilin/proline isomerasesearch Chitinase A; domain 3search PF00254: FKBP-type peptidyl-prolyl cis-trans isomerasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P62942) peptidyl-prolyl cis-trans isomerase activitysearch ryanodine-sensitive calcium-release channel activitysearch type I transforming growth factor beta receptor bindingsearch protein bindingsearch macrolide bindingsearch transforming growth factor beta receptor bindingsearch FK506 bindingsearch SMAD bindingsearch transforming growth factor beta-activated receptor activitysearch ion channel bindingsearch calcium channel inhibitor activitysearch isomerase activitysearch activin bindingsearch signal transducer activitysearch heart trabecula formationsearch heart morphogenesissearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of immune responsesearch transforming growth factor beta receptor signaling pathwaysearch protein foldingsearch regulation of amyloid precursor protein catabolic processsearch protein peptidyl-prolyl isomerizationsearch regulation of activin receptor signaling pathwaysearch chaperone-mediated protein foldingsearch 'de novo' protein foldingsearch calcium ion transmembrane transportsearch ventricular cardiac muscle tissue morphogenesissearch positive regulation of protein ubiquitinationsearch negative regulation of protein phosphatase type 2B activitysearch T cell activationsearch extracellular fibril organizationsearch protein refoldingsearch negative regulation of release of sequestered calcium ion into cytosolsearch protein maturation by protein foldingsearch positive regulation of protein bindingsearch amyloid fibril formationsearch SMAD protein complex assemblysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of protein localizationsearch Z discsearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch membranesearch terminal cisternasearch endoplasmic reticulum membranesearch

Chain InterPro annotation
A, B Peptidyl-prolyl cis-trans isomerase, FKBP-type, domainsearch Peptidyl-prolyl cis-trans isomerase, FKBP-typesearch