1d6m Summary

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CRYSTAL STRUCTURE OF E. COLI DNA TOPOISOMERASE III

The structure was published by Mondragon, A. and DiGate, R., in 1999 in a paper entitled "The structure of Escherichia coli DNA topoisomerase III." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of DNA TOPOISOMERASE III. This molecule has the UniProt identifier P14294 (TOP3_ECOLI)search. The sample contained 653 residues which is 100% of the natural sequence. Out of 653 residues 603 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DNA TOPOISOMERASE III P14294 (1-653) (TOP3_ECOLI)search Escherichia coli K-12search 100% 653 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P14294 (1 - 653) DNA TOPOISOMERASE III Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P14294) Prokaryotic type I DNA topoisomerasesearch Rossmann foldsearch, Topoisomerase I, domain 2search, Topoisomerase I, domain 3search, Topoisomerase I, domain 4search PF01131: DNA topoisomerasesearch, PF01751: Toprim domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P14294) DNA topological changesearch chromosome separationsearch DNA recombinationsearch DNA topoisomerase activitysearch DNA bindingsearch DNA topoisomerase type I activitysearch metal ion bindingsearch magnesium ion bindingsearch isomerase activitysearch

Chain InterPro annotation
A DNA topoisomerase, type IAsearch DNA topoisomerase, type IA, domain 2search DNA topoisomerase, type IA, DNA-binding domainsearch DNA topoisomerase IIIsearch Toprim domainsearch DNA topoisomerase, type IA, centralsearch DNA topoisomerase, type IA, central region, subdomain 1search DNA topoisomerase, type IA, central region, subdomain 2search DNA topoisomerase, type IA, core domainsearch DNA topoisomerase, type IA, active sitesearch