Function and Biology Details
Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase, type IA, central
- TOPRIM domain
- DNA topoisomerase III
- DNA topoisomerase, type IA, active site
- DNA topoisomerase, type IA, central region, subdomain 3
- DNA topoisomerase, type IA, DNA-binding domain
- DNA topoisomerase, type IA, central region, subdomain 2
- DNA topoisomerase, type IA, central region, subdomain 1
4 more domains
Structure domain:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
DNA topoisomerase 3 (preferred)
PDBe Complex ID:
PDB-CPX-146897 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 3
Molecule details ›
Chain: A
Length: 653 amino acids
Theoretical weight: 73.32 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 653 amino acids
Theoretical weight: 73.32 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
- Canonical:
P14294 (Residues: 1-653; Coverage: 100%)
Sequence domains:
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
CHESS BEAMLINE A1
Spacegroup:
P6122
Expression system: Escherichia coli
