spacer CRYSTAL STRUCTURE OF E. COLI DNA TOPOISOMERASE III
Primary citation
Title The structure of Escherichia coli DNA topoisomerase III.
Authors Mondragon, A.search; DiGate, R.search
Journal STRUCTUREsearch vol:7, pag:1373-1383 (1999), Identifiers: PubMed ID (10574789)search DOI (10.1016/S0969-2126(00)80027-1)
Abstract DNA topoisomerases are enzymes that change the topology of DNA. Type IA topoisomerases transiently cleave one DNA strand in order to pass another strand or strands through the break. In this manner, they can relax negatively supercoiled DNA and catenate and decatenate DNA molecules. Structural information on Escherichia coli DNA topoisomerase III is important for understanding the mechanism of this type of enzyme and for studying the mechanistic differences among different members of the same subfamily.
MeSH terms Amino Acid Sequencesearch, Binding Sitessearch, Crystallographysearch, X-Raysearch, DNA Topoisomerasessearch, Type Isearch, DNA-Binding Proteinssearch, Escherichia colisearch, Modelssearch, Molecularsearch, Molecular Sequence Datasearch, Protein Conformationsearch, Sequence Homologysearch, Amino Acidsearch
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