1d6i Summary

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CHALCONE SYNTHASE (H303Q MUTANT)

The structure was published by Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., and Noel, J.P., in 2000 in a paper entitled "Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CHALCONE SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHALCONE SYNTHASE P30074 (2-389) (CHS2_MEDSA)search Medicago sativasearch 99% 388 100%
B CHALCONE SYNTHASE P30074 (2-389) (CHS2_MEDSA)search Medicago sativasearch 99% 388 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P30074 (2 - 389) CHALCONE SYNTHASE Medicago sativa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P30074) Chalcone synthase-likesearch Peroxisomal Thiolase; Chain A, domain 1search PF00195: Chalcone and stilbene synthases, N-terminal domainsearch, PF02797: Chalcone and stilbene synthases, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P30074) metabolic processsearch flavonoid biosynthetic processsearch chalcone biosynthetic processsearch biosynthetic processsearch transferase activity, transferring acyl groupssearch naringenin-chalcone synthase activitysearch transferase activitysearch catalytic activitysearch transferase activity, transferring acyl groups other than amino-acyl groupssearch

Chain InterPro annotation
A, B Chalcone/stilbene synthase, N-terminalsearch Polyketide synthase, type IIIsearch Chalcone/stilbene synthase, C-terminalsearch Thiolase-like, subgroupsearch Thiolase-likesearch Chalcone/stilbene synthase, active sitesearch