1d66 Summary

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DNA RECOGNITION BY GAL4: STRUCTURE OF A PROTEIN/DNA COMPLEX

The structure was published by Marmorstein, R., Carey, M., Ptashne, M., and Harrison, S.C., in 1992 in a paper entitled "DNA recognition by GAL4: structure of a protein-DNA complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*AP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*TP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), and PROTEIN (GAL4).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (GAL4) P04386 (1-65) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 66 86%
B PROTEIN (GAL4) P04386 (1-65) (GAL4_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 66 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04386 (1 - 65) PROTEIN (GAL4) Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Zn2/Cys6 DNA-binding domainsearch, Leucine zipper domainsearch CD2-Gal4search, Single helix binsearch Fungal Zn(2)-Cys(6) binuclear cluster domainsearch, Gal4-like dimerisation domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P04386) sequence-specific DNA binding transcription factor activitysearch zinc ion bindingsearch sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Zn(2)-C6 fungal-type DNA-binding domainsearch Aflatoxin biosynthesis regulatory proteinsearch Gal4 dimerisation domainsearch