1d4w Summary

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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE

The structure was published by Poy, F., Yaffe, M.B., Sayos, J., et al., Cantley, L.C., Terhorst, C., and Eck, M.J., in 1999 in a paper entitled "Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely T CELL SIGNAL TRANSDUCTION MOLECULE SAP and SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A T CELL SIGNAL TRANSDUCTION MOLECULE SAP O60880 (1-104) (SH21A_HUMAN)search Homo sapienssearch 100% 104 100%
B T CELL SIGNAL TRANSDUCTION MOLECULE SAP O60880 (1-104) (SH21A_HUMAN)search Homo sapienssearch 100% 104 100%
C SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE Q13291 (276-286) (SLAF1_HUMAN)search Homo sapienssearch < 90% 11 90%
D SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE Q13291 (276-286) (SLAF1_HUMAN)search Homo sapienssearch < 90% 11 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
O60880 (1 - 104) T CELL SIGNAL TRANSDUCTION MOLECULE SAP Homo sapiens
Q13291 (276 - 286) SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (O60880) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
C, D
Chain InterPro annotation
A, B SH2 domainsearch
C, D