1d4a Summary

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CRYSTAL STRUCTURE OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AT 1.7 A RESOLUTION

The structure was published by Faig, M., Bianchet, M.A., Talalay, P., et al., Winski, S., Ross, D., and Amzel, L.M., in 2000 in a paper entitled "Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of QUINONE REDUCTASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A QUINONE REDUCTASE P15559 (2-274) (NQO1_HUMAN)search Homo sapienssearch 99% 273 100%
B QUINONE REDUCTASE P15559 (2-274) (NQO1_HUMAN)search Homo sapienssearch 99% 273 100%
C QUINONE REDUCTASE P15559 (2-274) (NQO1_HUMAN)search Homo sapienssearch 99% 273 100%
D QUINONE REDUCTASE P15559 (2-274) (NQO1_HUMAN)search Homo sapienssearch 99% 273 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15559 (2 - 274) QUINONE REDUCTASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P15559) Quinone reductasesearch Rossmann foldsearch PF02525: Flavodoxin-like foldsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P15559) cellular nitrogen compound metabolic processsearch response to ethanolsearch small molecule metabolic processsearch oxidation-reduction processsearch regulation of cellular amino acid metabolic processsearch removal of superoxide radicalssearch response to oxidative stresssearch negative regulation of catalytic activitysearch superoxide metabolic processsearch response to nutrientsearch positive regulation of neuron apoptotic processsearch synaptic transmission, cholinergicsearch xenobiotic metabolic processsearch response to estradiolsearch response to organic cyclic compoundsearch nitric oxide biosynthetic processsearch agingsearch response to toxic substancesearch cytosolsearch extracellular vesicular exosomesearch cytoplasmsearch neuronal cell bodysearch protein bindingsearch NAD(P)H dehydrogenase (quinone) activitysearch poly(A) RNA bindingsearch cytochrome-b5 reductase activity, acting on NAD(P)Hsearch superoxide dismutase activitysearch oxidoreductase activitysearch

Chain InterPro annotation
A, B, C, D Flavodoxin-like foldsearch Flavoprotein-likesearch