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EBI PDBe PDBeView

PDBe Entry: 1d3h view

HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.8 Å, R-factor: 16.2%, Free R-factor: 18.5%, Spacegroup: P 32 2 1
Released 13/08/2000, deposition: 29/09/1999, last revision: 24/02/2009
Authors Liu, S.search; Neidhardt, E.A.search; Grossman, T.H.search; Ocain, T.search; Clardy, J.search
Primary citation Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
STRUCTUREsearch vol:8, pag:25-33 (2000) [PubMed ID 10673429 ]search
Keywords ALPHA-BETA BARRELsearch, MEMBRANE BINDING MOTIFsearch, OXIDOREDUCTASEsearch
EC 1.3.5.2 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Dihydroorotate dehydrogenase, mitochondrial precursor (EC 1.3.3.1) (DHOdehase) (Dihydroorotate oxidase) Q02127search (A)
Solvent A
Related entries 1d3g
Polymers
Id Name Type UniProt Residues Observed
A DIHYDROOROTATE DEHYDROGENASE Protein Q02127 (PYRD_HUMAN)search
 367 99%
Heterogens
Id Name Ligands
A SULFATE ION SO4 search
A ACETATE ION ACT search
A 2-CYANO-3-HYDROXY-N-(4-TRIFLUOROMETHYL-PHENYL)-BUTYRAMIDE A26 search
A FLAVIN MONONUCLEOTIDE FMN search
A OROTIC ACID ORO search
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