1d3g Summary

pdbe.org/1d3g
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HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG

The structure was published by Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., and Clardy, J., in 2000 in a paper entitled "Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of DIHYDROOROTATE DEHYDROGENASE. This molecule has the UniProt identifier Q02127 (PYRD_HUMAN)search. The sample contained 367 residues which is 93% of the natural sequence. Out of 367 residues 360 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DIHYDROOROTATE DEHYDROGENASE Q02127 (29-395) (PYRD_HUMAN)search Homo sapienssearch 92% 367 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02127 (29 - 395) DIHYDROOROTATE DEHYDROGENASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q02127) FMN-linked oxidoreductasessearch Aldolase class Isearch PF01180: Dihydroorotate dehydrogenasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q02127) mitochondrial inner membranesearch integral to membranesearch neuronal cell bodysearch mitochondrionsearch membranesearch pyrimidine nucleotide biosynthetic processsearch regulation of mitochondrial fissionsearch oxidation-reduction processsearch 'de novo' pyrimidine nucleobase biosynthetic processsearch UMP biosynthetic processsearch response to drugsearch response to caffeinesearch pyrimidine nucleoside biosynthetic processsearch response to starvationsearch female pregnancysearch lactationsearch small molecule metabolic processsearch 'de novo' UMP biosynthetic processsearch pyrimidine nucleobase metabolic processsearch response to organic cyclic compoundsearch positive regulation of apoptotic processsearch nucleobase-containing small molecule metabolic processsearch dihydroorotate oxidase activitysearch FMN bindingsearch dihydroorotate dehydrogenase activitysearch catalytic activitysearch oxidoreductase activitysearch ubiquinone bindingsearch drug bindingsearch

Chain InterPro annotation
A Dihydroorotate dehydrogenase, conserved sitesearch Dihydroorotate dehydrogenase, class 2search Dihydroorotate dehydrogenase, class 1/ 2search Aldolase-type TIM barrelsearch