1d2h Summary



The structure was published by Huang, Y., Komoto, J., Konishi, K., et al., Gomi, T., Fujioka, M., and Takusagawa, F., in 2000 in a paper entitled "Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of GLYCINE N-METHYLTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCINE N-METHYLTRANSFERASE P13255 (2-293) (GNMT_RAT)search Rattus norvegicussearch 100% 292 86%
B GLYCINE N-METHYLTRANSFERASE P13255 (2-293) (GNMT_RAT)search Rattus norvegicussearch 100% 292 86%
C GLYCINE N-METHYLTRANSFERASE P13255 (2-293) (GNMT_RAT)search Rattus norvegicussearch 100% 292 86%
D GLYCINE N-METHYLTRANSFERASE P13255 (2-293) (GNMT_RAT)search Rattus norvegicussearch 100% 292 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13255 (2 - 293) GLYCINE N-METHYLTRANSFERASE Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P13255) Glycine N-methyltransferasesearch Glycine N-methyltransferase, chain A, domain 1search, Vaccinia Virus protein VP39search PF12847: Methyltransferase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P13255) glycine N-methyltransferase activitysearch folic acid bindingsearch glycine bindingsearch S-adenosylmethionine-dependent methyltransferase activitysearch transferase activitysearch methyltransferase activitysearch cytosolsearch nucleussearch cytoplasmsearch glycine metabolic processsearch S-adenosylhomocysteine metabolic processsearch S-adenosylmethionine metabolic processsearch protein tetramerizationsearch sarcosine metabolic processsearch protein homotetramerizationsearch methylationsearch folic acid metabolic processsearch

Chain InterPro annotation
A, B, C, D Glycine/Sarcosine N-methyltransferasesearch S-adenosyl-L-methionine-dependent methyltransferasesearch