1d2a Summary

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CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE ACTIVATOR ADENINE

The structure was published by Wang, S., Stauffacher, C.V., and Van Etten, R.L., in 2000 in a paper entitled "Structural and mechanistic basis for the activation of a low-molecular weight protein tyrosine phosphatase by adenine." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TYROSINE PHOSPHATASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE PHOSPHATASE P40347 (2-161) (PPAL_YEAST)search Saccharomyces cerevisiae S288csearch 99% 160 97%
B TYROSINE PHOSPHATASE P40347 (2-161) (PPAL_YEAST)search Saccharomyces cerevisiae S288csearch 99% 160 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P40347 (2 - 161) TYROSINE PHOSPHATASE Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P40347) Low-molecular-weight phosphotyrosine protein phosphatasessearch Rossmann foldsearch PF01451: Low molecular weight phosphotyrosine protein phosphatasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P40347) protein dephosphorylationsearch peptidyl-tyrosine dephosphorylationsearch protein tyrosine phosphatase activitysearch acid phosphatase activitysearch hydrolase activitysearch phosphoprotein phosphatase activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Protein-tyrosine phosphatase/arsenate reductasesearch Protein-tyrosine phosphatase, low molecular weightsearch Phosphotyrosine protein phosphatase I superfamilysearch