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PDBe Entry: 1d1x 
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,4-PBITU (H4B BOUND)
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OXIDOREDUCTASE
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X-RAY DIFFRACTION
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Resolution: 2.0 Å, R-factor: 22.0%, Free R-factor: 25.4%, Spacegroup: P 21 21 21
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25/07/2001, deposition: 21/09/1999, last revision: 24/02/2009
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Raman, C.S.; Li, H.; Martasek, P.; Southan, G.J.; Masters, B.S.S.; Poulos, T.L.
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Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
J.BIOL.CHEM. vol:276, pag:26486-26491 (2001) [PubMed ID 11331290 ]
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AHPHA-BETA FOLD, oxidoreductase
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1.14.13.39 ExPASy BRENDA (A B)
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Bos taurus(cattle) 9913(A B)
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Nitric oxide synthase, endothelial (EC 1.14.13.39) (Endothelial NOS) (eNOS) (EC-NOS) (NOS type III) (NOSIII) (Constitutive NOS) (cNOS) P29473 (A B)
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A, B
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1nse, 1d0c, 1d0o, 1d0p, 1d1v, 1d1w, 1d1x, 1d1y
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| A, B |
BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN |
Protein |
P29473 (NOS3_BOVIN)
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444 |
93% |
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| A, B |
ACETATE ION |
ACT
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| A |
ZINC ION |
ZN
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| A, B |
PROTOPORPHYRIN IX CONTAINING FE |
HEM
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| A, B |
5,6,7,8-TETRAHYDROBIOPTERIN |
H4B
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| A, B |
2-{2-[4-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ETHYL}-ISOTHIOUREA |
4BT
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| A, B |
CACODYLIC ACID |
CAD
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| A, B |
GLYCEROL |
GOL
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