› 1d11

X-ray diffraction
1.18Å resolution

INTERACTIONS BETWEEN AN ANTHRACYCLINE ANTIBIOTIC AND DNA MOLECULAR STRUCTURE OF DAUNOMYCIN COMPLEXED TO D(CPGPTPAPCPG) AT 1.2-ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1d11/pdb
PDB entry 1d11 coloured by chain, front view.
PDB entry 1d11 coloured by chain, side view.
PDB entry 1d11 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Interactions between an anthracycline antibiotic and DNA: molecular structure of daunomycin complexed to d(CpGpTpApCpG) at 1.2-A resolution.
Wang AH, Ughetto G, Quigley GJ, Rich A
Biochemistry 26 1152-63 (1987)
PMID: 3567161

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113571 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand DM1 1 x DM1
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 27.86Å b: 27.86Å c: 52.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 not available not available
Expression system: Not provided

Quick links

Citations

23 review citations

The role of carbohydrates in biologically active natural products.
Weymouth-Wilson AC. (1997)
22 more

30 mentions without citation

Immunotherapeutic approaches to curtail COVID-19.
Owji et al. (2020)
29 more