› 1czv

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN COAGULATION FACTOR V: DIMERIC CRYSTAL FORM

Released:
DOI: 10.2210/pdb1czv/pdb
PDB entry 1czv coloured by chain, front view.
PDB entry 1czv coloured by chain, side view.
PDB entry 1czv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P
Nature 402 434-9 (1999)
PMID: 10586886

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor V light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P12259 (Residues: 2065-2224; Coverage: 7%)
Gene name: F5
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 86.52Å b: 70.54Å c: 60.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.257
Expression system: Not provided

Quick links

Citations

33 review citations

Membrane recognition by phospholipid-binding domains.
Lemmon MA. (2008)
32 more

4 mentions without citation

Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
Lin et al. (2007)
3 more