1cx2 Summary

pdbe.org/1cx2
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CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (Q05769) heme bindingsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch enzyme bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch oxidoreductase activitysearch metal ion bindingsearch dioxygenase activitysearch lipid bindingsearch protein homodimerization activitysearch response to oxidative stresssearch bone mineralizationsearch positive regulation of transforming growth factor beta productionsearch cellular response to mechanical stimulussearch negative regulation of synaptic transmission, dopaminergicsearch hair cyclesearch regulation of cell proliferationsearch negative regulation of cell cyclesearch oxidation-reduction processsearch positive regulation of smooth muscle cell proliferationsearch cellular response to ATPsearch positive regulation of synaptic transmission, glutamatergicsearch response to lipopolysaccharidesearch cellular response to hypoxiasearch inflammatory responsesearch positive regulation of fever generationsearch response to lithium ionsearch sensory perception of painsearch angiogenesissearch positive regulation of vasoconstrictionsearch prostaglandin metabolic processsearch positive regulation of apoptotic processsearch response to drugsearch prostaglandin biosynthetic processsearch positive regulation of cell migration involved in sprouting angiogenesissearch response to cytokinesearch response to manganese ionsearch response to organonitrogen compoundsearch memorysearch positive regulation of smooth muscle contractionsearch fatty acid metabolic processsearch cyclooxygenase pathwaysearch negative regulation of calcium ion transportsearch positive regulation of fibroblast growth factor productionsearch keratinocyte differentiationsearch regulation of blood pressuresearch positive regulation of synaptic plasticitysearch negative regulation of smooth muscle contractionsearch positive regulation of brown fat cell differentiationsearch response to organic substancesearch response to vitamin Dsearch fatty acid biosynthetic processsearch lipid metabolic processsearch response to tumor necrosis factorsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of platelet-derived growth factor productionsearch positive regulation vascular endothelial growth factor productionsearch negative regulation of cell proliferationsearch anagensearch response to fatty acidsearch decidualizationsearch response to fructosesearch response to organic cyclic compoundsearch positive regulation of cell deathsearch positive regulation of NF-kappaB import into nucleussearch response to radiationsearch maintenance of blood-brain barriersearch response to estradiolsearch learningsearch ovulationsearch embryo implantationsearch cellular response to UVsearch response to glucocorticoidsearch brown fat cell differentiationsearch cytoplasmsearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch neuron projectionsearch organelle membranesearch protein complexsearch endoplasmic reticulum membranesearch membranesearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search