1cwe Summary

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HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE

The structure was published by Mikol, V., Baumann, G., Keller, T.H., Manning, U., and Zurini, M.G., in 1995 in a paper entitled "The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely P56LCK TYROSINE KINASE and PHOSPHOPEPTIDE ACQ-PMP-GLU-GLU-ILE-PRO.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P56LCK TYROSINE KINASE P06239 (127-222) (LCK_HUMAN)search Homo sapienssearch < 90% 98 100%
C P56LCK TYROSINE KINASE P06239 (127-222) (LCK_HUMAN)search Homo sapienssearch < 90% 98 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06239 (127 - 222) P56LCK TYROSINE KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, C SH2 domainsearch