1cvu Summary

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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

The structure was published by Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., et al., Marnett, L.J., Stallings, W.C., and Kurumbail, R.G., in 2000 in a paper entitled "Structural insights into the stereochemistry of the cyclooxygenase reaction." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROSTAGLANDIN H2 SYNTHASE-2 and PROTEIN (9-MER).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN H2 SYNTHASE-2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
B PROSTAGLANDIN H2 SYNTHASE-2 Q05769 (18-569) (PGH2_MOUSE)search Mus musculussearch 94% 552 100%
F PROTEIN (9-MER) Not available
Not available Not available 9 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 569) PROSTAGLANDIN H2 SYNTHASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch
F

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) response to oxidative stresssearch oxidation-reduction processsearch inflammatory responsesearch response to vitamin Dsearch response to organonitrogen compoundsearch cellular response to UVsearch negative regulation of smooth muscle contractionsearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation of fever generationsearch response to cytokinesearch cyclooxygenase pathwaysearch regulation of blood pressuresearch cellular response to mechanical stimulussearch response to glucocorticoidsearch response to estradiolsearch response to lipopolysaccharidesearch anagensearch prostaglandin biosynthetic processsearch response to lithium ionsearch positive regulation of nitric oxide biosynthetic processsearch fatty acid metabolic processsearch response to fatty acidsearch regulation of cell proliferationsearch response to radiationsearch cellular response to ATPsearch response to manganese ionsearch learningsearch prostaglandin metabolic processsearch positive regulation of smooth muscle cell proliferationsearch ovulationsearch fatty acid biosynthetic processsearch maintenance of blood-brain barriersearch keratinocyte differentiationsearch positive regulation of NF-kappaB import into nucleussearch response to drugsearch sensory perception of painsearch positive regulation of platelet-derived growth factor productionsearch hair cyclesearch response to fructosesearch response to tumor necrosis factorsearch brown fat cell differentiationsearch memorysearch angiogenesissearch lipid metabolic processsearch positive regulation of fibroblast growth factor productionsearch positive regulation of synaptic plasticitysearch response to organic substancesearch bone mineralizationsearch negative regulation of cell proliferationsearch positive regulation vascular endothelial growth factor productionsearch response to organic cyclic compoundsearch negative regulation of synaptic transmission, dopaminergicsearch positive regulation of vasoconstrictionsearch positive regulation of transforming growth factor beta productionsearch positive regulation of cell deathsearch decidualizationsearch negative regulation of cell cyclesearch positive regulation of smooth muscle contractionsearch negative regulation of calcium ion transportsearch positive regulation of brown fat cell differentiationsearch cellular response to hypoxiasearch embryo implantationsearch positive regulation of apoptotic processsearch positive regulation of cell migration involved in sprouting angiogenesissearch peroxidase activitysearch heme bindingsearch prostaglandin-endoperoxide synthase activitysearch metal ion bindingsearch enzyme bindingsearch dioxygenase activitysearch lipid bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch protein homodimerization activitysearch oxidoreductase activitysearch membranesearch cytoplasmsearch neuron projectionsearch organelle membranesearch endoplasmic reticulum membranesearch protein complexsearch endoplasmic reticulumsearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search
F