1cve Summary

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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE

The structure was published by Ippolito, J.A. and Christianson, D.W., in 1994 in a paper entitled "Structural consequences of redesigning a protein-zinc binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch regulation of anion transportsearch response to pHsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch response to organic substancesearch response to estrogensearch angiotensin-activated signaling pathwaysearch response to zinc ionsearch small molecule metabolic processsearch kidney developmentsearch extracellular vesicular exosomesearch membranesearch cytoplasmsearch cytosolsearch apical part of cellsearch basolateral plasma membranesearch plasma membranesearch axonsearch myelin sheathsearch microvillussearch extracellular spacesearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch