1cvd Summary

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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE

The structure was published by Ippolito, J.A. and Christianson, D.W., in 1994 in a paper entitled "Structural consequences of redesigning a protein-zinc binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 255 residues which is 98% of the natural sequence. Out of 255 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (5-259) (CAH2_HUMAN)search Homo sapienssearch 98% 255 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (5 - 259) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) plasma membranesearch cytosolsearch microvillussearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch apical part of cellsearch myelin sheathsearch axonsearch basolateral plasma membranesearch protein bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch zinc ion bindingsearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch positive regulation of cellular pH reductionsearch secretionsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch regulation of intracellular pHsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch kidney developmentsearch regulation of chloride transportsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch