1cva Summary

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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II

The structure was published by Krebs, J.F., Ippolito, J.A., Christianson, D.W., and Fierke, C.A., in 1993 in a paper entitled "Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) axonsearch extracellular spacesearch myelin sheathsearch cytosolsearch extracellular vesicular exosomesearch microvillussearch plasma membranesearch cytoplasmsearch apical part of cellsearch membranesearch basolateral plasma membranesearch bicarbonate transportsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch positive regulation of osteoclast differentiationsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch secretionsearch regulation of intracellular pHsearch response to zinc ionsearch regulation of chloride transportsearch response to pHsearch one-carbon metabolic processsearch kidney developmentsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch response to estrogensearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch