1ctp Summary

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STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION

The structure was published by Karlsson, R., Zheng, J., Xuong, N., Taylor, S.S., and Sowadski, J.M., in 1993 in a paper entitled "Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely cAMP-DEPENDENT PROTEIN KINASE and cAMP-dependent protein kinase inhibitor, alpha form.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E cAMP-DEPENDENT PROTEIN KINASE P36887 (2-351) (KAPCA_PIG)search Sus scrofasearch 100% 350 95%
I cAMP-dependent protein kinase inhibitor, alpha form P61926 (6-25) (IPKA_RABIT)search Oryctolagus cuniculussearch < 90% 20 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P36887 (2 - 351) cAMP-DEPENDENT PROTEIN KINASE Sus scrofa
P61926 (6 - 25) cAMP-dependent protein kinase inhibitor, alpha form Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P36887) Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch
I cAMP-dependent protein kinase inhibitorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
E (P36887) protein phosphorylationsearch phosphorylationsearch mitochondrionsearch membranesearch cytoplasmsearch plasma membranesearch nucleussearch kinase activitysearch transferase activitysearch cAMP-dependent protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch
I (P61926) negative regulation of protein kinase activitysearch cAMP-dependent protein kinase inhibitor activitysearch

Chain InterPro annotation
E Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
I cAMP-dependent protein kinase inhibitorsearch