1csb Summary

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Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors

The structure was published by Turk, D., Podobnik, M., Popovic, T., et al., Bode, W., Huber, R., and Turk, V., in 1995 in a paper entitled "Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CATHEPSIN B light chain and CATHEPSIN B heavy chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CATHEPSIN B light chain P07858 (80-126) (CATB_HUMAN)search Homo sapienssearch < 90% 47 100%
D CATHEPSIN B light chain P07858 (80-126) (CATB_HUMAN)search Homo sapienssearch < 90% 47 100%
B CATHEPSIN B heavy chain P07858 (129-333) (CATB_HUMAN)search Homo sapienssearch < 90% 205 100%
E CATHEPSIN B heavy chain P07858 (129-333) (CATB_HUMAN)search Homo sapienssearch < 90% 205 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07858 (80 - 126) CATHEPSIN B light chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D Papain-likesearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Papain family cysteine proteasesearch
B, E Papain-likesearch Cysteine proteinasessearch Papain family cysteine proteasesearch
Chain InterPro annotation
A, D Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch
B, E Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Peptidase C1A, cathepsin Bsearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch