1cs8 Summary



The structure has not been published. The depositing authors are Cygler, M.search; Coulombe, R.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HUMAN PROCATHEPSIN L. This molecule has the UniProt identifier P07711 (CATL1_HUMAN)search. The sample contained 316 residues which is 100% of the natural sequence. Out of 316 residues 315 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HUMAN PROCATHEPSIN L P07711 (19-333) (CATL1_HUMAN)search Homo sapienssearch 99% 316 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07711 (19 - 333) HUMAN PROCATHEPSIN L Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P07711) Papain-likesearch Cysteine proteinasessearch PF00112: Papain family cysteine proteasesearch, PF08246: Cathepsin propeptide inhibitor domain (I29)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P07711) peptidase activitysearch cysteine-type endopeptidase activitysearch protein bindingsearch histone bindingsearch proteoglycan bindingsearch hydrolase activitysearch fibronectin bindingsearch cysteine-type peptidase activitysearch collagen bindingsearch collagen catabolic processsearch proteolysis involved in cellular protein catabolic processsearch adaptive immune responsesearch proteolysissearch extracellular matrix disassemblysearch toll-like receptor signaling pathwaysearch antigen processing and presentationsearch innate immune responsesearch cellular response to thyroid hormone stimulussearch extracellular matrix organizationsearch macrophage apoptotic processsearch antigen processing and presentation of exogenous peptide antigen via MHC class IIsearch extracellular vesicular exosomesearch extracellular regionsearch endolysosome lumensearch lysosomal lumensearch lysosomesearch nucleussearch extracellular spacesearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Proteinase inhibitor I29, cathepsin propeptidesearch Cysteine peptidase, histidine active sitesearch Cysteine peptidase, asparagine active sitesearch