› 1crp

Solution NMR

THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY

Released:
DOI: 10.2210/pdb1crp/pdb
PDB entry 1crp coloured by chain, ensemble of 20 models, front view.
PDB entry 1crp coloured by chain, ensemble of 20 models, side view.
PDB entry 1crp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.
Kraulis PJ, Domaille PJ, Campbell-Burk SL, Van Aken T, Laue ED
Biochemistry 33 3515-31 (1994)
PMID: 8142349

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.88 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

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Citations

18 review citations

G protein mechanisms: insights from structural analysis.
Sprang SR. (1997)
17 more

14 mentions without citation

The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.
von Lintig et al. (2010)
13 more