1cra Summary

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THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE

The structure was published by Mangani, S. and Liljas, A., in 1993 in a paper entitled "Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 260 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch zinc ion bindingsearch lyase activitysearch myelin sheathsearch cytosolsearch apical part of cellsearch basolateral plasma membranesearch plasma membranesearch extracellular spacesearch cytoplasmsearch membranesearch axonsearch extracellular vesicular exosomesearch microvillussearch regulation of intracellular pHsearch bicarbonate transportsearch positive regulation of bone resorptionsearch kidney developmentsearch response to estrogensearch angiotensin-activated signaling pathwaysearch response to organic substancesearch one-carbon metabolic processsearch response to steroid hormonesearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch secretionsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch positive regulation of synaptic transmission, GABAergicsearch response to zinc ionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch positive regulation of osteoclast differentiationsearch odontogenesis of dentin-containing toothsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch