1cqq Summary



The structure was published by Matthews, D.A., Dragovich, P.S., Webber, S.E., et al., Brothers, M.A., DeLisle, D.M., and Worland, S.T., in 1999 in a paper entitled "Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of TYPE 2 RHINOVIRUS 3C PROTEASE. This molecule has the UniProt identifier P04936 (POLG_HRV2)search. The sample contained 180 residues which is < 90% of the natural sequence. Out of 180 residues 178 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYPE 2 RHINOVIRUS 3C PROTEASE P04936 (1508-1687) (POLG_HRV2)search Human rhinovirus A2search < 90% 180 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04936 (1508 - 1687) TYPE 2 RHINOVIRUS 3C PROTEASE Human rhinovirus A2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Viral cysteine protease of trypsin foldsearch Trypsin-like serine proteasessearch 3C cysteine protease (picornain 3C)search

Chain ID Molecular function (GO) Biological process (GO)
A (P04936) cysteine-type endopeptidase activitysearch catalytic activitysearch proteolysissearch

Chain InterPro annotation
A Peptidase C3A/C3B, picornaviralsearch Trypsin-like cysteine/serine peptidase domainsearch