1cqe Summary

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PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN

The structure was published by Picot, D., Loll, P.J., and Garavito, R.M., in 1994 in a paper entitled "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) P05979 (21-600) (PGH1_SHEEP)search Ovis ariessearch 96% 580 95%
B PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) P05979 (21-600) (PGH1_SHEEP)search Ovis ariessearch 96% 580 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05979 (21 - 600) PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) Ovis aries

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05979) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P05979) response to oxidative stresssearch oxidation-reduction processsearch inflammatory responsesearch cyclooxygenase pathwaysearch prostaglandin biosynthetic processsearch regulation of blood pressuresearch prostaglandin-endoperoxide synthase activitysearch peroxidase activitysearch heme bindingsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 1search