1coy Summary

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CRYSTAL STRUCTURE OF CHOLESTEROL OXIDASE COMPLEXED WITH A STEROID SUBSTRATE. IMPLICATIONS FOR FAD DEPENDENT ALCOHOL OXIDASES

The structure was published by Li, J., Vrielink, A., Brick, P., and Blow, D.M., in 1993 in a paper entitled "Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1993.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CHOLESTEROL OXIDASE. This molecule has the UniProt identifier P22637 (CHOD_BREST)search. The sample contained 507 residues which is 100% of the natural sequence. Out of 507 residues 495 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHOLESTEROL OXIDASE P22637 (46-552) (CHOD_BREST)search Brevibacterium sterolicumsearch 100% 507 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22637 (46 - 552) CHOLESTEROL OXIDASE Brevibacterium sterolicum

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P22637) FAD-linked reductases, N-terminal domainsearch, GMC oxidoreductasessearch FAD/NAD(P)-binding domainsearch, Cholesterol Oxidase; domain 2search PF00732: GMC oxidoreductasesearch, PF05199: GMC oxidoreductasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P22637) oxidation-reduction processsearch cholesterol metabolic processsearch steroid metabolic processsearch lipid metabolic processsearch extracellular regionsearch oxidoreductase activity, acting on CH-OH group of donorssearch cholesterol oxidase activitysearch isomerase activitysearch steroid delta-isomerase activitysearch oxidoreductase activitysearch flavin adenine dinucleotide bindingsearch

Chain InterPro annotation
A Glucose-methanol-choline oxidoreductase, N-terminalsearch Glucose-methanol-choline oxidoreductase, C-terminalsearch