1coh Summary

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STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS

The structure was published by Luisi, B. and Shibayama, N., in 1989 in a paper entitled "Structure of haemoglobin in the deoxy quaternary state with ligand bound at the alpha haems." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch positive regulation of cell deathsearch heme bindingsearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch extracellular vesicular exosomesearch blood microparticlesearch membranesearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolsearch cytosolic small ribosomal subunitsearch
B, D (P68871) oxygen transportsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch regulation of blood pressuresearch small molecule metabolic processsearch blood coagulationsearch nitric oxide transportsearch renal absorptionsearch platelet aggregationsearch regulation of blood vessel sizesearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch oxygen bindingsearch hemoglobin bindingsearch heme bindingsearch haptoglobin bindingsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch