1coh Summary

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STRUCTURE OF HAEMOGLOBIN IN THE DEOXY QUATERNARY STATE WITH LIGAND BOUND AT THE ALPHA HAEMS

The structure was published by Luisi, B. and Shibayama, N., in 1989 in a paper entitled "Structure of haemoglobin in the deoxy quaternary state with ligand bound at the alpha haems." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1989.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (FERROUS CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (COBALTOUS DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch membranesearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch receptor-mediated endocytosissearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B, D (P68871) heme bindingsearch oxygen transporter activitysearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch hemoglobin complexsearch cytosolsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch regulation of blood pressuresearch oxygen transportsearch blood coagulationsearch nitric oxide transportsearch renal absorptionsearch platelet aggregationsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch response to hydrogen peroxidesearch transportsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch