1cnx Summary

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SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS

The structure was published by Boriack, P.A., Christianson, D.W., Kingery-Wood, J., and Whitesides, G.M., in 1995 in a paper entitled "Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch cytoplasmsearch plasma membranesearch cytosolsearch membranesearch extracellular spacesearch extracellular vesicular exosomesearch apical part of cellsearch myelin sheathsearch axonsearch basolateral plasma membranesearch microvillussearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch bicarbonate transportsearch secretionsearch small molecule metabolic processsearch response to steroid hormonesearch positive regulation of bone resorptionsearch response to zinc ionsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch regulation of intracellular pHsearch response to pHsearch positive regulation of osteoclast differentiationsearch response to estrogensearch morphogenesis of an epitheliumsearch kidney developmentsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch