1cnw Summary

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SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS

The structure was published by Boriack, P.A., Christianson, D.W., Kingery-Wood, J., and Whitesides, G.M., in 1995 in a paper entitled "Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch cytosolsearch apical part of cellsearch extracellular vesicular exosomesearch plasma membranesearch microvillussearch axonsearch myelin sheathsearch membranesearch extracellular spacesearch basolateral plasma membranesearch response to zinc ionsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch response to estrogensearch secretionsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch odontogenesis of dentin-containing toothsearch bicarbonate transportsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch response to organic substancesearch response to pHsearch one-carbon metabolic processsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch