1cnj Summary



The structure was published by Lesburg, C.A. and Christianson, D.W., in 1995 in a paper entitled "X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) response to zinc ionsearch positive regulation of osteoclast differentiationsearch response to organic substancesearch one-carbon metabolic processsearch response to stresssearch positive regulation of bone resorptionsearch response to estrogen stimulussearch angiotensin-mediated signaling pathwaysearch bicarbonate transportsearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormone stimulussearch secretionsearch carbon dioxide transportsearch kidney developmentsearch response to pHsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch plasma membranesearch apical part of cellsearch cytosolsearch cytoplasmsearch membranesearch basolateral plasma membranesearch extracellular spacesearch axonsearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2/13search Carbonic anhydrase, alpha-classsearch