1cni Summary



The structure was published by Lesburg, C.A. and Christianson, D.W., in 1995 in a paper entitled "X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch plasma membranesearch cytosolsearch cytoplasmsearch apical part of cellsearch axonsearch basolateral plasma membranesearch extracellular vesicular exosomesearch extracellular spacesearch myelin sheathsearch membranesearch microvillussearch positive regulation of cellular pH reductionsearch response to zinc ionsearch bicarbonate transportsearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch one-carbon metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch regulation of anion transportsearch positive regulation of bone resorptionsearch response to pHsearch response to steroid hormonesearch kidney developmentsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch secretionsearch response to organic substancesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch