1cnc Summary

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COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES

The structure was published by Ippolito, J.A. and Christianson, D.W., in 1994 in a paper entitled "Structural consequences of redesigning a protein-zinc binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) myelin sheathsearch cytoplasmsearch extracellular spacesearch cytosolsearch basolateral plasma membranesearch apical part of cellsearch plasma membranesearch microvillussearch axonsearch membranesearch extracellular vesicular exosomesearch bicarbonate transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch response to organic substancesearch response to zinc ionsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch regulation of anion transportsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch kidney developmentsearch response to estrogensearch positive regulation of osteoclast differentiationsearch secretionsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch