1cnb Summary

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COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES

The structure was published by Ippolito, J.A. and Christianson, D.W., in 1994 in a paper entitled "Structural consequences of redesigning a protein-zinc binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of chloride transportsearch regulation of intracellular pHsearch kidney developmentsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch bicarbonate transportsearch response to pHsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch one-carbon metabolic processsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch response to zinc ionsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch response to steroid hormonesearch positive regulation of bone resorptionsearch response to estrogensearch axonsearch membranesearch plasma membranesearch apical part of cellsearch myelin sheathsearch cytosolsearch cytoplasmsearch microvillussearch extracellular vesicular exosomesearch basolateral plasma membranesearch extracellular spacesearch zinc ion bindingsearch lyase activitysearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch