1cmy Summary

pdbe.org/1cmy
spacer

THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN

The structure was published by Smith, F.R., Lattman, E.E., and Carter Jr., C.W., in 1991 in a paper entitled "The mutation beta 99 Asp-Tyr stabilizes Y--a new, composite quaternary state of human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch membranesearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch transportsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch
B, D (P68871) protein bindingsearch oxygen bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch haptoglobin bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch oxygen transportsearch oxidation-reduction processsearch small molecule metabolic processsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch renal absorptionsearch regulation of blood vessel sizesearch bicarbonate transportsearch regulation of blood pressuresearch blood coagulationsearch hydrogen peroxide catabolic processsearch transportsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch nitric oxide transportsearch positive regulation of cell deathsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch