1cmy Summary

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THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN

The structure was published by Smith, F.R., Lattman, E.E., and Carter Jr., C.W., in 1991 in a paper entitled "The mutation beta 99 Asp-Tyr stabilizes Y--a new, composite quaternary state of human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch protein bindingsearch haptoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch heme bindingsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxygen transportsearch transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch oxidation-reduction processsearch hemoglobin complexsearch membranesearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch cytosolic small ribosomal subunitsearch blood microparticlesearch endocytic vesicle lumensearch
B, D (P68871) iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch platelet aggregationsearch nitric oxide transportsearch transportsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch protein heterooligomerizationsearch regulation of blood pressuresearch oxidation-reduction processsearch blood coagulationsearch hydrogen peroxide catabolic processsearch hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular regionsearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch