1cmy Summary

pdbe.org/1cmy
spacer

THE MUTATION BETA99 ASP-TYR STABILIZES Y-A NEW, COMPOSITE QUATERNARY STATE OF HUMAN HEMOGLOBIN

The structure was published by Smith, F.R., Lattman, E.E., and Carter Jr., C.W., in 1991 in a paper entitled "The mutation beta 99 Asp-Tyr stabilizes Y--a new, composite quaternary state of human hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN YPSILANTI (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch bicarbonate transportsearch response to hydrogen peroxidesearch extracellular regionsearch hemoglobin complexsearch membranesearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch
B, D (P68871) oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch protein bindingsearch heme bindingsearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch nitric oxide transportsearch positive regulation of cell deathsearch transportsearch regulation of blood pressuresearch small molecule metabolic processsearch platelet aggregationsearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch blood coagulationsearch hydrogen peroxide catabolic processsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch