1cmx Summary

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STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES

The structure was published by Johnston, S.C., Riddle, S.M., Cohen, R.E., and Hill, C.P., in 1999 in a paper entitled "Structural basis for the specificity of ubiquitin C-terminal hydrolases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTEIN (UBIQUITIN YUH1-UBAL).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (UBIQUITIN YUH1-UBAL) P35127 (1-235) (UBL1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 235 91%
C PROTEIN (UBIQUITIN YUH1-UBAL) P35127 (1-235) (UBL1_YEAST)search Saccharomyces cerevisiae S288csearch 100% 235 91%
B PROTEIN (UBIQUITIN YUH1-UBAL) P0CG48 (609-684) (UBC_HUMAN)search Homo sapienssearch < 90% 76 100%
D PROTEIN (UBIQUITIN YUH1-UBAL) P0CG48 (609-684) (UBC_HUMAN)search Homo sapienssearch < 90% 76 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35127 (1 - 235) PROTEIN (UBIQUITIN YUH1-UBAL)
P0CG48 (609 - 684) PROTEIN (UBIQUITIN YUH1-UBAL)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P35127) Ubiquitin carboxyl-terminal hydrolase UCH-Lsearch Ubiquitin C-terminal Hydrolase Uch-l3search PF01088: Ubiquitin carboxyl-terminal hydrolase, family 1search
B, D Ubiquitin-relatedsearch Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1search Ubiquitin familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P35127) cytoplasmsearch cysteine-type peptidase activitysearch peptidase activitysearch hydrolase activitysearch ubiquitin-specific protease activitysearch ubiquitin homeostasissearch proteolysissearch

Chain InterPro annotation
A, C Peptidase C12, ubiquitin carboxyl-terminal hydrolasesearch
B, D Ubiquitin-likesearch Ubiquitin conserved sitesearch Ubiquitinsearch Ubiquitin-related domainsearch