1cll Summary



The structure was published by Chattopadhyaya, R., Meador, W.E., Means, A.R., and Quiocho, F.A., in 1992 in a paper entitled "Calmodulin structure refined at 1.7 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CALMODULIN. This molecule has the UniProt identifier P62158 (CALM_HUMAN)search. The sample contained 148 residues which is 99% of the natural sequence. Out of 148 residues 143 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62158) calcium ion bindingsearch ion channel bindingsearch protein domain specific bindingsearch protein kinase bindingsearch protein bindingsearch metal ion bindingsearch enzyme regulator activitysearch protein N-terminus bindingsearch phospholipase bindingsearch nitric-oxide synthase regulator activitysearch protein phosphatase activator activitysearch calcium-dependent protein bindingsearch type 3 metabotropic glutamate receptor bindingsearch titin bindingsearch protein serine/threonine kinase activator activitysearch N-terminal myristoylation domain bindingsearch adenylate cyclase bindingsearch phosphatidylinositol 3-kinase bindingsearch thioesterase bindingsearch nitric-oxide synthase bindingsearch nucleoplasmsearch neuron projectionsearch cytosolsearch plasma membranesearch spindlesearch nucleussearch extracellular vesicular exosomesearch cytoplasmsearch spindle microtubulesearch centrosomesearch calcium channel complexsearch sarcomeresearch spindle polesearch vesiclesearch growth conesearch cytoskeletonsearch extracellular regionsearch positive regulation of cyclic nucleotide metabolic processsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of heart ratesearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch inositol phosphate metabolic processsearch detection of calcium ionsearch nitric oxide metabolic processsearch calcium-mediated signalingsearch synaptic transmissionsearch small molecule metabolic processsearch regulation of cytokinesissearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of ryanodine-sensitive calcium-release channel activitysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch response to corticosteronesearch platelet degranulationsearch muscle contractionsearch regulation of rhodopsin mediated signaling pathwaysearch membrane organizationsearch positive regulation of nitric-oxide synthase activitysearch regulation of nitric-oxide synthase activitysearch Fc-epsilon receptor signaling pathwaysearch signal transductionsearch blood coagulationsearch regulation of high voltage-gated calcium channel activitysearch positive regulation of protein dephosphorylationsearch epidermal growth factor receptor signaling pathwaysearch G-protein coupled receptor signaling pathwaysearch positive regulation of protein serine/threonine kinase activitysearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch activation of phospholipase C activitysearch glucose metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch fibroblast growth factor receptor signaling pathwaysearch innate immune responsesearch rhodopsin mediated signaling pathwaysearch positive regulation of phosphoprotein phosphatase activitysearch carbohydrate metabolic processsearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch substantia nigra developmentsearch glycogen catabolic processsearch response to calcium ionsearch phototransduction, visible lightsearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch platelet activationsearch activation of adenylate cyclase activitysearch response to amphetaminesearch regulation of cardiac muscle contractionsearch negative regulation of peptidyl-threonine phosphorylationsearch positive regulation of protein autophosphorylationsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch