1cjy Summary



The structure was published by Dessen, A., Tang, J., Schmidt, H., et al., Clark, J.D., Seehra, J., and Somers, W.S., in 1999 in a paper entitled "Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2) P47712 (1-749) (PA24A_HUMAN)search Homo sapienssearch 100% 749 84%
B PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2) P47712 (1-749) (PA24A_HUMAN)search Homo sapienssearch 100% 749 84%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47712 (1 - 749) PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P47712) PLC-like (P variant)search, Lysophospholipasesearch C2- domain Calcium/lipid binding domainsearch, Cytosolic phospholipase A2 catalytic domainsearch PF00168: C2 domainsearch, PF01735: Lysophospholipase catalytic domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P47712) phospholipid catabolic processsearch phosphatidylethanolamine acyl-chain remodelingsearch glycerophospholipid biosynthetic processsearch phosphatidylserine acyl-chain remodelingsearch small molecule metabolic processsearch icosanoid metabolic processsearch phospholipid metabolic processsearch platelet activating factor biosynthetic processsearch metabolic processsearch phosphatidylinositol acyl-chain remodelingsearch cardiolipin acyl-chain remodelingsearch phosphatidic acid biosynthetic processsearch arachidonic acid secretionsearch lipid catabolic processsearch platelet activationsearch lipid metabolic processsearch arachidonic acid metabolic processsearch phosphatidylglycerol acyl-chain remodelingsearch cellular response to antibioticsearch phosphatidylcholine acyl-chain remodelingsearch blood coagulationsearch regulation of cell proliferationsearch icosanoid biosynthetic processsearch lysophospholipase activitysearch phospholipase A2 activitysearch phospholipase activitysearch metal ion bindingsearch calcium-dependent phospholipase A2 activitysearch calcium ion bindingsearch hydrolase activitysearch calcium-dependent phospholipid bindingsearch cytosolsearch endoplasmic reticulumsearch cytoplasmsearch mitochondrial inner membranesearch endoplasmic reticulum membranesearch Golgi apparatussearch cytoplasmic vesiclesearch cytoplasmic membrane-bounded vesiclesearch

Chain InterPro annotation
A, B C2 domainsearch Lysophospholipase, catalytic domainsearch Acyl transferase/acyl hydrolase/lysophospholipasesearch