1cj1 Summary details

pdbe.org/1cj1/summary_details
spacer GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
Summary
Header SIGNALING PROTEINsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 3.0 Å, R-factor: 30.47%, Free R-factor: 31.7%, Spacegroup: P 21 21 21
Released 22/12/1999, deposition: 21/04/1999, last revision: 24/02/2009
Authors Rahuel, J.search
Primary citation Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
J.MED.CHEM.search vol:42, pag:2358-2363 (1999) [PubMed 10395476 ]search
Keywords SIGNAL TRANSDUCTIONsearch, SH2 DOMAINsearch, PHOSPHOTYROSINEsearch, SIGNALING PROTEINsearch
Organism Homo sapiens(human) 9606search(A B C D E F G H I J K L)
UniProt P62993search (A B C D E F G H I J K L)
Solvent A
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, B, C, D, E, F, G, H, I, J, K, L PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) Protein P62993 (GRB2_HUMAN)search
96 100%
Heterogens
Chain Id Name Ligands
A, B, C, D, E, F, G, H, I, J, K, L [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER C78 search
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