1cj1 Summary

pdbe.org/1cj1
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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE

The structure was published by Furet, P., Garcia-Echeverria, C., Gay, B., Schoepfer, J., Zeller, M., and Rahuel, J., in 1999 in a paper entitled "Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
B PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
C PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
D PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
E PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
F PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
G PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
H PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
I PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
J PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
K PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%
L PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) P62993 (57-152) (GRB2_HUMAN)search Homo sapienssearch 100% 96 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (57 - 152) PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch
Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L SH2 domainsearch Growth factor receptor-bound protein 2search