1cim Summary

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THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS

The structure was published by Smith, G.M., Alexander, R.S., Christianson, D.W., et al., Randall, W.C., Baldwin, J.J., and Habecker, C.N., in 1994 in a paper entitled "Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1993.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 96% 259 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) one-carbon metabolic processsearch regulation of intracellular pHsearch bicarbonate transportsearch response to steroid hormonesearch response to estrogensearch positive regulation of dipeptide transmembrane transportsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch response to zinc ionsearch positive regulation of synaptic transmission, GABAergicsearch secretionsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch kidney developmentsearch response to pHsearch response to organic substancesearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch regulation of chloride transportsearch positive regulation of cellular pH reductionsearch cellular response to fluid shear stresssearch regulation of anion transportsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch cytoplasmsearch extracellular spacesearch extracellular vesicular exosomesearch apical part of cellsearch cytosolsearch plasma membranesearch basolateral plasma membranesearch membranesearch myelin sheathsearch axonsearch microvillussearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch