1cg6 Summary

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STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-DEOXY-5'-METHYLTHIOADENOSINE AND SULFATE AT 1.7 A RESOLUTION

The structure was published by Appleby, T.C., Erion, M.D., and Ealick, S.E., in 1999 in a paper entitled "The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7 A resolution provides insights into substrate binding and catalysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of PROTEIN (5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE). This molecule has the UniProt identifier Q13126 (MTAP_HUMAN)search. The sample contained 283 residues which is 100% of the natural sequence. Out of 283 residues 268 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE) Q13126 (1-283) (MTAP_HUMAN)search Homo sapienssearch 100% 283 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13126 (1 - 283) PROTEIN (5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q13126) Purine and uridine phosphorylasessearch Rossmann foldsearch PF01048: Phosphorylase superfamilysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q13126) S-methyl-5-thioadenosine phosphorylase activitysearch transferase activity, transferring pentosyl groupssearch catalytic activitysearch phosphorylase activitysearch transferase activitysearch transferase activity, transferring glycosyl groupssearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch cytosolsearch nucleoside metabolic processsearch L-methionine biosynthetic process from methylthioadenosinesearch sulfur amino acid metabolic processsearch cellular nitrogen compound metabolic processsearch polyamine metabolic processsearch small molecule metabolic processsearch nicotinamide riboside catabolic processsearch purine ribonucleoside salvagesearch nucleobase-containing compound metabolic processsearch

Chain InterPro annotation
A Nucleoside phosphorylase domainsearch PNP/MTAP phosphorylasesearch Methylthioadenosine phosphorylase (MTAP)search Purine phosphorylase, family 2, conserved sitesearch