1cfa Summary

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SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES

The structure was published by Zhang, X., Boyar, W., Galakatos, N., and Gonnella, N.C., in 1997 in a paper entitled "Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding." (abstract).

The structure was determined using NMR spectroscopy and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST and SYNTHETIC N-TERMINAL TAIL.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST P01031 (679-747) (CO5_HUMAN)search Homo sapienssearch 95% 71 100%
B SYNTHETIC N-TERMINAL TAIL Not available
Not available Not available 4 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01031 (679 - 747) COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P01031) Anaphylotoxins (complement system)search Influenza Virus Matrix Protein; Chain A, domain 1search PF01821: Anaphylotoxin-like domainsearch
B

Chain ID Cellular component (GO) Biological process (GO)
A (P01031) extracellular regionsearch inflammatory responsesearch complement activationsearch

Chain InterPro annotation
A Anaphylatoxin/fibulinsearch Anaphylatoxin, complement system domainsearch Anaphylatoxin, complement systemsearch
B