› 1cdo

X-ray diffraction
2.05Å resolution

ALCOHOL DEHYDROGENASE (E.C.1.1.1.1) (EE ISOZYME) COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD), AND ZINC

Released:
DOI: 10.2210/pdb1cdo/pdb
PDB entry 1cdo coloured by chain, front view.
PDB entry 1cdo coloured by chain, side view.
PDB entry 1cdo coloured by chain, top view.
Source organism: Gadus morhua callarias
Primary publication:
Crystal structure of cod liver class I alcohol dehydrogenase: substrate pocket and structurally variable segments.
Ramaswamy S, el Ahmad M, Danielsson O, Jörnvall H, Eklund H
Protein Sci 5 663-71 (1996)
PMID: 8845755

Function and Biology Details

Reaction catalysed: 
A primary alcohol + NAD(+) = an aldehyde + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alcohol dehydrogenase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 374 amino acids
Theoretical weight: 40.05 KDa
Source organism: Gadus morhua callarias
UniProt:
  • Canonical: P26325 (Residues: 1-374; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 102.95Å b: 47.6Å c: 80.43Å
α: 90° β: 104.66° γ: 90°
R-values:
R R work R free
0.177 0.177 0.248

Quick links

Citations

2 review citations

Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.
Duester G. (2000)
1 more

9 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
8 more